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Md Ashraf Mokhtar1, Mohd Aftab Ahmad1, Qudsia Nizami1, Farhan Jalees Ahmad2, Md Mahfoozur Rahman3
1Department of Pharmacology, Faculty of Medicine, Jamia Hamdard, New Delhi-110062, India.
2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India.
3Department of Pharmacology, Nizamia Unani Medical College, Dumri, via Buniad Ganj, Rasoolpur , Gaya-823001, India.

 

ORIGINAL RESEARCH ARTICLE
Volume 2, Issue 1, Jan-April 2014.

Article history
Received: 22 March 2014
Revised: 10 April 2014
Accepted: 23 April 2014
Early view: 28 April 2014

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Keywords:
Incision wound
Excision wound
Tensile strength
Framycetin
Epithelialization.

ABSTRACTObjective: The aim of the present study was to verify the wound healing claims of a Unani formulation Marham-e-Ral on different experimental models of wounds in albino rats.
Material and methods: Marham-e-Ral was prepared as per classical method. The animals were divided into three groups of six each. The parameters studied were wound contraction, epithelialisation period and tensile strength.
Results: Marham-e-Ral showed wound healing activity, with almost 98.9% healing on 15th day, whereas in the control only 90% healing took place. In the incision wound studies, there was a significant increase in tensile strength on day 10 due to treatment with standard cream (31.90 + 0.026) and Marham-e-Ral (16.48 ± 0.022) when compared with control group i.e. 8.388 + 0.128 (P ≤ 0.01). The histopathological slides clearly showed the extent of healing and demonstrated significant improvement.
Conclusion: Marham-e-Ral showed a wholesome effect on wound healing in excision wound model and the effect was found equally comparable to the standard drug framycetin cream.