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Ansari JA1*, Abdul Mateen Syed2, Md Faruque Ahmad3, Mirza Anwar Baig4
1Department of Pharmacology, MESCO College of Pharmacy, Mustaidpura, Karwan Road, Hyderabad-500006, TS, India.
2Department of Pharmacology, Oriental College of Pharmacy, Sector-2, Sanpada (W), Navi Mumbai-400705, India.
3College of Applied Medical Sciences, Jazan University, Jazan, KSA.
4School of Pharmacy, Anjuman-I-Islam’s, Kalsekar Technical Campus, Panvel-410206, MS, India.

ORIGINAL RESEARCH ARTICLE
Volume 2, Issue 3, Page 142-147, September-December 2014.

Article history
Received: 10 November 2014
Revised: 30 November 2014
Accepted: 15 December 2014
Early view: 30 December 2014

*Author for correspondence
E-mail: javed.ansari47@gmail.com

ABSTRACT

Background: The leaves of Aegle marmelos (L.) Correa (AM) is widely used by tribal people of Chidambaram district (Tamilnadu, India) for the treatment of Jaundice and other liver diseases. Aim of the present study was to evaluate the medicinal potential ethanolic extract of AM as hepatoprotective and antioxidant against acetaminophen-induced liver damage.
Material and methods: The hepatoprotective activity of ethanol extract of AM was evaluated by acetaminophen-induced liver damage and antioxidant activity was evaluated using in vivo antioxidant models viz. lipid peroxidation assay and glutathione estimation in liver. Liver function tests were measured to detect hepatoprotective activity, which was further supported by histopathological examination.
Results: Ethanol extract of AM reduced elevated level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin significantly which was comparable to standard drug Silymarin in acetaminophen treated Wistar rats (P < 0.01). Further, ethanol extract of AM was found to reduce the elevated levels of lipid peroxidation product malondialdehyde (MDA), and enhance the reduced level of glutathione in liver proving antioxidant activity comparable with Silymarin.
Conclusion: Aegle marmelos (L.) Correa posses hepatoprotective property and may be effective in oxidative stress-induced cholestatic hepatic injury.
Keywords: Antioxidant, Hepatoprotective; Glutathione; Histopathology; Lipid Peroxidation.