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Surinder K. Sharma1,3, Mohammed Ali2*, Harneet Singh1, Shahnaz Sultana2,4, Showkat R. Mir2.
1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar – 125 001 (Haryana), INDIA.
2Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, INDIA.
3Herbal Drug Technology, Delhi Pharmaceutical Science and Research University, Puspvihar, Sector 3, New Delhi 110 017, INDIA.
4College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA.

Volume 2017, Issue 2017, Article ID 125, Page 01-07.

*Author for correspondence

Background: Jatropha curcas L. (Euphorbiaceae), is grown in tropical and subtropical regions of the world mainly in Africa, Asia, and Pacific region. The plant is used to treat allergies, burns, cuts, cough, diabetes, diarrhea, gum diseases, herpes, leucoderma, skin diseases, paralysis, piles, splenomegaly, toothache, tumors, ulcers, whitlow, warts, and syphilis. Our study was planned to isolate chemical constituents from the rhizomes of C. rotundus and to characterize their structures.
Material and methods: The air-dried root powder was exhaustively extracted with methanol and the concentrated extract was adsorbed on silica gel (60-120 mesh) for the preparation of slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol, successively, in order of increasing polarity to isolate the compounds.
Results: Phytochemical investigation of the roots led to isolate 2-hydroxybenzyl n-octanoate (salicyl caprylate, 1), 2-hydroxybenzyl n-dodecanoate (salicyl laurate, 2), benzyl n-tetradecanoate (benzyl myristate, 3), n-butanoyl-β-D-glucofuranoside (4), 2β-D-galactopyranosyloxybenzyl n-hexanoate (2β-D-galactosyloxybenzyl caproate, 5), 2β-D-glucopyranosyloxybenzyl n-octanoate (2 β-D-glucopyranosyloxybenzyl caprylate , 6) and n-caproyl O-β-D-glucopyranosyl-(2ʹ→1ʹʹ)-O-β-D-glucopyranoside (n-caproyl diglucoside, 7). The structures of these compounds have been established on the basis of spectral data analysis and chemical means.
Conclusion: The roots of J. curcas possessed three aromatic esters, their glycosides and acyl glucosides.
Keywords: Jatropha curcas L., Roots, Chemical constituents, Isolation, Characterization.