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Srinivasa Rao A1, Mohammed Fazil Ahmed2*

1Bhaskar Pharmacy College, Yeknapally, Moinabad (Mandal), RR (Dist), Hyderabad-500075, India.
2Nizam Institute of Pharmacy & Research Center, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda-508284, AP, India.

ORIGINAL RESEARCH ARTICLE
ARTICLE INFORMATION

Article history
Received: 05 December 2013
Revised: 15 December 2013
Accepted: 20 December 2013
Early view: 29 December 2013

*Author for correspondence
E-mail: mohdfazil_pharma@yahoo.co.in
Mobile/ Tel.: 0000000000

Keywords:
Periwinkle
Silymarin
Vinca rosea
SGOT
SGPT
ALP.

ABSTRACT

Background: The main aim of the present study is to evaluate the hepatoprotective activity of ethanolic extract of Catharanthus rosea L. leaves against simvastatin-induced hepatotoxicity in rats.
Materials and methods: The phytochemical study was also carried out on the ethanolic extract of Catharanthus rosea leaves. Hepatotoxicity was induced by simvastatin (20 mg/kg p.o. for 30 days) in Wistar rats. The hepatoprotective effect was evaluated by extract of Catharanthus rosea leaves (300 mg/kg and 500 mg/kg for 30 days).
Results: The observation of the phytochemical investigations includes the presence of alkaloids, tannins, saponins, glycosides, phenols, and flavonoids. There was significant changes in biochemical parameters e.g. increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP), serum bilirubin and decrease the total protein contents in Catharanthus rosea (300 mg/kg and 500 mg/kg) treated animals. The results were comparable to standard hepatoprotective drug Silymarin (25 mg/kg).
Conclusion: Thus the present study ascertains that the ethanolic extract of Catharanthus rosea leaves possesses significant hepatoprotective activity.