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Lakshmi BVS *, Sudhakar M, Aparna M
Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally Maisammaguda, Secunderabad-500014, AP, India.

ORIGINAL RESEARCH ARTICLE
Volume 2, Issue 1, Jan-April 2014, Page 25-29.

Article history
Received: 04 April 2014
Revised: 20 April 2014
Accepted: 26 April 2014
Early view: 28 April 2014

*Author for correspondence
E-mail: adithya.neha@gmail.com

Keywords:
Cadmium
Vitis vinifera
Antioxidants
Nephrotoxicity.

ABSTRACT
Background: Cadmium (Cd) is a major environmental pollutant and is known for its wide toxic manifestations. The protective effect of concurrent administration of black grapes (Vitis vinifera) on cadmium-induced renal damage was assessed in rats.
Material and methods: In the present investigation cadmium (5 mg/kg) was administered orally for 4 weeks to induce nephrotoxicity in rats.
Results: Tissue damage induced by cadmium was clearly shown by increased activities of renal markers-serum creatinine and blood urea nitrogen (BUN) along with the increased level of lipid peroxidation indices-TBARS, significantly diminished levels of enzymatic antioxidants such as superoxide dismutases (SOD), catalase, and non-enzymatic antioxidants viz. glutathione (GSH). Administration of black grapes extract significantly reversed activities of serum renal markers to their near-normal levels, significantly decreased lipid peroxidation, restored the antioxidant defense levels of in kidney, and produced improvement in hematological parameters when compared to cadmium-treated rats.
Conclusion: The present study suggested that black grapes may be beneficial in ameliorating the cadmium-induced oxidative damage in the kidneys of rats.