Farhan Akhtar1*, Misbahuddin Azhar2, Mohd Aslam3, Kaleem Javed4.
1Government Unani Hospital, Asara, Baghpat, U.P., INDIA.
2Regional Research Institute of Unani Medicine, Aligarh, U.P., INDIA.
3School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, INDIA.
4Dept. of Chemistry, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi, INDIA.
RESEARCH ARTICLE
Volume 9, Issue 2, Page 45-50
*Author for correspondence
E-mail: [email protected]
ABSTRACT
Background: Gentamicin is a broad-spectrum antibiotic of aminoglycoside family with nephrotoxicity is a major clinical drawback. This study was conducted to analyze the effect of Asgand (Withania somnifera Dunal) powder (AP) as antinephrotoxic with gentamicin intramuscular in male albino rats.
Methodology: Animals were given 100 mg/kg body weight gentamicin with Asgnad powder in the dose of 700 and 1400 mg/kg body wt/day three days prior and concomitant for five days to gentamicin.
Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in blood urea (577%), Serum creatinine (129%), and Uric acid (166%). The oral administration of AP (700mg / kg) inhibited the rise in blood urea (68.1%), serum creatinine (80.6%), and uric acid (107.5%). There was 71.6% inhibition in the rise of BUN, 103% inhibition in the rise of serum creatinine, and 83.1% inhibition in the rise of uric acid with 1400mg (AS).
Conclusion: These results indicated that asgand powder is antinephrotoxic in both doses against gentamicin-induced nephrotoxicity in rats. It may be concluded that Asgand powder could be an antinephrotoxic agent. Further exploration of nephroprotective activity against other nephrotoxic agents may be conducted in different experimental animal models.
Keywords: Withania somnifera Dunal, Gentamicin, Asgand, Antinephrotoxic, Nephroprotection, Unani Medicine.
Background: Gentamicin is a broad-spectrum antibiotic of aminoglycoside family with nephrotoxicity is a major clinical drawback. This study was conducted to analyze the effect of Asgand (Withania somnifera Dunal) powder (AP) as antinephrotoxic with gentamicin intramuscular in male albino rats.
Methodology: Animals were given 100 mg/kg body weight gentamicin with Asgnad powder in the dose of 700 and 1400 mg/kg body wt/day three days prior and concomitant for five days to gentamicin.
Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in blood urea (577%), Serum creatinine (129%), and Uric acid (166%). The oral administration of AP (700mg / kg) inhibited the rise in blood urea (68.1%), serum creatinine (80.6%), and uric acid (107.5%). There was 71.6% inhibition in the rise of BUN, 103% inhibition in the rise of serum creatinine, and 83.1% inhibition in the rise of uric acid with 1400mg (AS).
Conclusion: These results indicated that asgand powder is antinephrotoxic in both doses against gentamicin-induced nephrotoxicity in rats. It may be concluded that Asgand powder could be an antinephrotoxic agent. Further exploration of nephroprotective activity against other nephrotoxic agents may be conducted in different experimental animal models.
Keywords: Withania somnifera Dunal, Gentamicin, Asgand, Antinephrotoxic, Nephroprotection, Unani Medicine.
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