Farhana Ataurrahman1*, Rasale SP1, Haroon Ansari2,
1Department of Chemistry,Prof. Ram Krishna More Arts, Commerce & Science College Akurdi, Pune-411044, MS, India.
2JAT Senior College Malegaon-422303, MS, India.
ORIGINAL RESEARCH ARTICLE
Volume 3, Issue 3, Page 137-141, September-December 2015.
Article history
Received: 5 December 2015
Revised: 10 December 2015
Accepted: 20 December 2015
Early view: 30 December 2015
*Author for correspondence
E-mail: [email protected]
ABSTRACT
Aim: The purpose of this study was to formulate and developed a novel topical polymeric film containing the antifungal agents.
Material and methods: Topical antifungal films of clotrimazole were designed with different polymers & permeation enhancers like HPMC-K-100, HEC, CMC, Ethyl-Cellulose, Eudragit S-100 and PVP K-30 etc. incorporated at different concentrations using the casting evaporation technique. Evaluations of these formulae were performed through mechanical characterizations and Fourier Transform Infrared Spectroscopy [FTIR]. In-vitro release studies were performed during 24 h using diffusion cells.
Results: From the preliminary screening of the six polymers based upon the rating system it was observed that the film formulated using polymer PVP K-30 shows the best result. Moreover the film obtained from PVP K-30 was found to be having self-adhesive property.
Conclusion: The polymeric film was found to be non-sticky (from the back) thus preventing adhesion to the clothes of the patient/other physical contact. Keywords: Topical antifungal film, clotrimazole, formulation and development.
Aim: The purpose of this study was to formulate and developed a novel topical polymeric film containing the antifungal agents.
Material and methods: Topical antifungal films of clotrimazole were designed with different polymers & permeation enhancers like HPMC-K-100, HEC, CMC, Ethyl-Cellulose, Eudragit S-100 and PVP K-30 etc. incorporated at different concentrations using the casting evaporation technique. Evaluations of these formulae were performed through mechanical characterizations and Fourier Transform Infrared Spectroscopy [FTIR]. In-vitro release studies were performed during 24 h using diffusion cells.
Results: From the preliminary screening of the six polymers based upon the rating system it was observed that the film formulated using polymer PVP K-30 shows the best result. Moreover the film obtained from PVP K-30 was found to be having self-adhesive property.
Conclusion: The polymeric film was found to be non-sticky (from the back) thus preventing adhesion to the clothes of the patient/other physical contact. Keywords: Topical antifungal film, clotrimazole, formulation and development.
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