Zeenat Iqbal1, Farhan J. Ahmad1, Manu Babbar2.
1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
2Gracure Pharmaceutical Limited, Shivaji Marg, New Delhi- 110015, India.
ORIGINAL RESEARCH ARTICLE
Volume 2016, Issue 2016, Article ID 99, Page 1-7.
ABSTRACT
Objective: The purpose of our research was to formulate an intra gastric retentive targeted effervescent drug delivery form of Ofloxacin and Ornidazole for eradication of H. Pylori infection in stomach.
Materials and Methods: The HBS system was developed using polymers HPMC K4M and Carbopol 934P to circumvent the unregulated release of conventional formulation while overwhelming the short gastric retention time and the intra-mucosal colonization of H. Pylori. Effervescent tablets were manufactured by slugging and evaluated for content uniformity, friability, hardness and dissolution.
Results: The desirable buoyancy of the formulation was achieved by addition of citric acid and calcium carbonate. The tablets hence prepared exhibited floating capacity for a targeted period of above 12 hours and released 98% drug which was suitably analyzed by HPLC analysis.
Conclusion: The current research work was a successful attempt at formulating and characterizing intra gastric retentive targeted effervescent type of floating drug delivery system containing a combination of Ofloxacin and Ornidazole for treatment of H. Pylori infection
Keywords: effervescent, gastro retentive, floating, H. Pylori, Ofloxacin, Ornidazole.
Objective: The purpose of our research was to formulate an intra gastric retentive targeted effervescent drug delivery form of Ofloxacin and Ornidazole for eradication of H. Pylori infection in stomach.
Materials and Methods: The HBS system was developed using polymers HPMC K4M and Carbopol 934P to circumvent the unregulated release of conventional formulation while overwhelming the short gastric retention time and the intra-mucosal colonization of H. Pylori. Effervescent tablets were manufactured by slugging and evaluated for content uniformity, friability, hardness and dissolution.
Results: The desirable buoyancy of the formulation was achieved by addition of citric acid and calcium carbonate. The tablets hence prepared exhibited floating capacity for a targeted period of above 12 hours and released 98% drug which was suitably analyzed by HPLC analysis.
Conclusion: The current research work was a successful attempt at formulating and characterizing intra gastric retentive targeted effervescent type of floating drug delivery system containing a combination of Ofloxacin and Ornidazole for treatment of H. Pylori infection
Keywords: effervescent, gastro retentive, floating, H. Pylori, Ofloxacin, Ornidazole.
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