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Wasim Ahmad1*, Ghufran Ahmad2, Khan NA2, Shamshad Ahmad3
1Department of Ilmul Advia, Mohammadia Tibbia College, Malegaon, Nashik, India
2Department of Ilmul Advia, Faculty of Unani Medicine, AMU, Aligarh, India
3Department of Pathology, J.N. Medical College, AMU, Aligarh, India.

Volume 3, Issue 1, Page 32-36, January-April 2015.

Article history
Received: 10 February 2015
Revised: 02 March 2015
Accepted: 10 March 2015
Early view: 15 April 2015

*Author for correspondence


In the present study the hydroalcoholic extract of Seeds of Carthamus tinctorius was investigated for its steroidal and metabolic activity in albino rats of either sex in twodifferent tests. In both the tests, the animals were treated with the test drug (100 mg/kg/p.o.) twice a day for three days and were sacrificed subsequently on day 4. Thymus gland was dissected out and weighed in the test for steroidal activity while in the test designed for metabolic activity, liver was dissected out for glycogen estimation and blood was collected for the estimation of blood sugar, serum protein and serum cholesterol. The test drug reduced the thymus weight significantly (p<0.01) as compared to the plain control. It also induced hyperproteinemic, hypocholesteraemic and liver glycogen increasing effect and moderately increased the blood glucose level. The findings suggest that the hydroalcoholic extract of seeds of Carthamus tinctorius possesses marked steroidal and metabolic activity. Steroidal effect may be one of the bases for its use in kidney diseases especially nephrotic syndrome like condition. Keywords: Steroidal activity, Metabolic activity, Carthamus tinctorius.