Javed Akhtar Ansari1*, Syed Abrarul Haq2, Mirza Anwar Baig3, Abu Sufyan Shaikh3
1Department of Pharmacology, MESCO College of Pharmacy, Hyderabad, TS, India.
2Department of Pharmacology, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, India.
3School of Pharmacy, Anjuman-I-Islam’s, Kalsekar Technical Campus, New Panvel, M.S., India.
ORIGINAL RESEARCH ARTICLE
Volume 3, Issue 1, Page 01-06, January-April 2015.
Article history
Received: 10 March 2015
Revised: 10 April 2015
Accepted: 12 April 2015
Early view: 20 April 2015
*Author for correspondence
E-mail: [email protected]
ABSTRACT
Background: Liver disease is one of the global medical problems which cause significant morbidity and mortality. In present study, hepatoprotective and antioxidant property of methanolic extract of Murraya koenigii L. (Rutaceae) were investigated in CCl4 induced hepatotoxicity in rats.
Material and methods: Hepatotoxicity was induced by CCl4 (2 ml/kg, i.p.) and silymarin was used as a standard drug. Before CCl4 intoxication, rats were treated with methanolic extract of Murraya koenigii L. at a dose of 50, 100 and 200mg/kg once day for 14 days. Treatment with a methanolic extract of Murraya koenigii L. showed significant hepatoprotective activity in CCl4 intoxicated rats which were indicated by reduction in the level of marker of hepatotoxicity. Treatment also showed significantly decreased in hepatic lipid peroxidation and a corresponding increase in tissue antioxidant enzyme.
Results: The results of present study demonstrate the hepatoprotective activity of methanolic extract of Murraya koenigii L. against CCl4-induced hepatotoxicity in rats which might be due to its anti-oxidant activity.
Conclusion: It suggests a potential therapeutic use of Murraya koenigii L. in treatment of acute liver diseases and oxidative stress.
Background: Liver disease is one of the global medical problems which cause significant morbidity and mortality. In present study, hepatoprotective and antioxidant property of methanolic extract of Murraya koenigii L. (Rutaceae) were investigated in CCl4 induced hepatotoxicity in rats.
Material and methods: Hepatotoxicity was induced by CCl4 (2 ml/kg, i.p.) and silymarin was used as a standard drug. Before CCl4 intoxication, rats were treated with methanolic extract of Murraya koenigii L. at a dose of 50, 100 and 200mg/kg once day for 14 days. Treatment with a methanolic extract of Murraya koenigii L. showed significant hepatoprotective activity in CCl4 intoxicated rats which were indicated by reduction in the level of marker of hepatotoxicity. Treatment also showed significantly decreased in hepatic lipid peroxidation and a corresponding increase in tissue antioxidant enzyme.
Results: The results of present study demonstrate the hepatoprotective activity of methanolic extract of Murraya koenigii L. against CCl4-induced hepatotoxicity in rats which might be due to its anti-oxidant activity.
Conclusion: It suggests a potential therapeutic use of Murraya koenigii L. in treatment of acute liver diseases and oxidative stress.
Keywords: Liver damage; hepatoprotective effect; antioxidant effect; Murraya koenigii L.
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