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Md Shoaib uddin Khateeb1*, Pawan Kumar1, Syed Safiullah Ghori2.
1School of Pharmacy and Medical Sciences, Singhania University, Rajasthan, India.
2Anwar ul Uloom College of Pharmacy, Hyderabad, Telangana, India.

Volume 9, Issue 3, Page 83-88.

*Author for correspondence

Background: Diabetes has become a common global health problem that affects >170 million people worldwide. Traditional medicines obtained from medicinal plants are used by about 40-60% of the world’s population. The present study focused on screening of polyherbal formulation for antidiabetic activity in rats.
Materials and Methods: The present study focused on screening of polyherbal formulation composed of Trigonella foenum-graecum L., Momordica charantia L. & Portulaca oleracea L. (300 mg/kg) in alloxan-induced diabetic rats (150 mg/kg) and with respect to enzymatic assay as such and α- amylase and α-glucosidase inhibition assay.
Results: Polyherbal formulation (PHF) extracts exhibited a significant reduction in α-amylase and α-glucosidase activity with respect to Acarbose, a standard antidiabetic drug. Bodyweight, blood glucose, total cholesterol, and triglycerides level were significantly reduced in PHF treated group as compared to the alloxan-induced diabetic (negative control) group.
Conclusion: The present study successfully demonstrated the antidiabetic activity of PHF in rats.
Keywords: Polyherbal formulation Phytochemicals, Alpha-amylase, Alpha-glucosidase Acarbose, Glibenclamide.