Background: :According to World Health Organization, about 80% of the world population relies on traditional systems of medicine for primary health care. The objective of the present study was to evaluate antihyperglycemic activity of aqueous and alcoholic extract of Girardinia diversifolia (AQGD and ALGD respectively).

Material and methods: : In the present study, the leaves of Girardinia diversifolia were subjected to successive extraction by using petroleum ether, chloroform, acetone, alcohol and water. Animals were divided into seven groups (n=6). Group I served as normal control (normal saline); group II served as alloxan diabetic control (120 mg/kg, i.p.); group III served as positive control, glibenclamide (10 mg/kg, p.o.); group IV and VII served as test groups, two doses of alcoholic extracts of Girardinia diversifolia (200 & 400 mg/kg p.o.), and two doses of aqueous extract of Girardinia diversifolia (200 and 400 mg/kg p.o.) respectively.
Results: The preliminary phytochemical investigation revealed the presence of alkaloids, carbohydrates, glycosides, saponins, proteins, flavonoids, tannins, and phenolic compounds. The present study showed significant antihyperglycemic effect on repeated administration of aqueous and alcoholic extract of Girardinia diversifolia in Wistar rats.
Conclusion: Based on the present study, it can be concluded that the alcoholic extract is having good antidiabetic activity as compared to aqueous extract of Girardinia diversifolia. Further experiments are required to isolate and identify the antioxidant and antidiabetic components, and assess the mechanism of action.