A prospective observational study on prescribing patterns of antihypertensive drugs in a teaching hospital

Aisha Rizwana Sayyada1*, Swathi Kandi1, Swetha Podila1, Farhath Unnisa1, Md. Ather Ali Soherwardi1, Ahmed Hussaini Syed1, Musa Khan2, Javed Akhtar Ansari1.

1Department of Pharmacy Practice (PharmD), MESCO College of Pharmacy, Mustaidpura, Hyderabad, India.
2Department of General Medicine, Osmania General Hospital (OGH), Afzal Gunj, Hyderabad, India.

ORIGINAL RESEARCH ARTICLE
Volume 2017, Issue 2017, Article ID 101, Page 1-7.

ABSTRACT
Background: Hypertension is a growing worldwide problem and presents an increased risk of cardiovascular disease. The aim of the present study was to determine the existing practices of prescribing pattern of antihypertensive medication in a teaching hospital of Hyderabad, Telangana, India. The prescribing pattern was investigated to ascertain whether it was in accordance with standard prescribing guidelines for hypertension (JNC-7).
Subject and Methods: A hospital-based prospective, observational study on prescribing patterns of antihypertensive drugs was carried out among patients who were above the age of 18 years and attending inpatient department. A total of 178 previously treated and untreated patients were included in the study to analyze the prescribing patterns and were evaluated according to JNC-7 guidelines.
Results: It was an observational, prospective, non-interventional study in which 178 patients met the inclusion criteria. 82% of the study populations were males; 78.65% were known hypertensive’s while 21.34% were de Novo hypertensive. The present study disclosed that a high proportion of the hypertensive patients were on dual therapy in which maximum combinations were of CCBs with ACE inhibitors (27.63%) which lead to the maximum reduction in systolic BP. CCBs were the most frequently prescribed class of drug in both mono and combination therapy while thiazide diuretics ranked last in our study.
Conclusion: Our study represents the current prescribing trends of antihypertensive agents. It was noted that calcium channel blockers were the most commonly prescribed class of drugs in both mono and combination therapy. Significant reduction in systolic and diastolic blood pressure was seen with ACE inhibitors.
Keywords: HTN, cardiovascular diseases, calcium channel blockers, diuretics, beta blockers, ACE inhibitors.