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Sayyed Mateen1*, Mohib Khan2, Devanna N3, Aziz-ur-Rahman1

1MESCO College of Pharmacy, Hyderabad-500006, India.
2Oriental College of Pharmacy, Mumbai-400705, India.
3OTRI-Jawaharlal Nehru Technological University, Anantapur, AP-515002, India.

ORIGINAL RESEARCH ARTICLE
ARTICLE INFORMATION

Article history
Received: 02 December 2013
Revised: 12 December 2013
Accepted: 15 December 2013
Early view: 29 December 2013

*Author for correspondence
E-mail: abdulmateenpharma@gmail.com
Mobile/ Tel.: +919052710095

Keywords:
Methanol
Muscular Rigidity
Catalepsy
Haloperidol.

ABSTRACT

Objective:To evaluate & establish the antiparkinsonian activity of methanolic extract of Hemidesmus indicus (MEHI) against haloperidol-induced parkinsonism in Swiss albino mice.
Materials and methods: In the present study the MEHI was prepared by successive solvent extraction (Soxhlet apparatus). Two doses i.e. 75 & 100 mg/kg of MEHI were evaluated for antiparkinsonian activity in haloperidol-induced parkinsonism (catalepsy) in albino mice. Benzhexol was used as standard drug (positive control).
Results: Pre-treatment of test animals with Hemidesmus indicus (75 & 100 mg/kg i.p) reduced the catalepsy score in haloperidol treated mice. Both the doses i.e. 75 & 100 mg/kg (i.p.) of Hemidesmus indicus showed protective effects against haloperidol-induced catalepsy.
Conclusion: The present study suggests that the Hemidesmus indicus has antiparkinsonian activity against haloperidol-induced parkinsonism in albino mice. Phenols and Tannins may be the responsible leads for the present study. Further, in- depth studies are needed to explore & establish the role of Terpenes and Phenolic content of Hemidesmus indicus for their antiparkinsonian mechanisms.