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MD Imad Uddin1*, Asma Butool S2, Saadia Zubedi S2, Selvi SK2, Manasa P2.

1Dept. of Pharmacology, Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram, SangaReddy, Telangana-502313.
2Dept. of pharmacology, MAK College of Pharmacy, Moinabad, Telangana-500075.

ORIGINAL RESEARCH ARTICLE
Volume 2016, Issue 2016, Article ID 98, Page 1-11.

ABSTRACT
Background: In the study, we investigated phytochemical composition, anti-inflammatory activity and anti-arthritic potential of Sterculia foetida L. bark extract for the first time.
Material and Methods:8 Phytochemical evaluation of bark extract was done by standard procedures. Anti-inflammatory activity was tested against carrageenan induced rat paw edema. Acute non-immunological Arthritis was induced by injecting formaldehyde on 1st and 3rd day in right hind paw of female Wistar rats; paw width and height were measured on alternate days up to 10th day. Animals were sacrificed on 10th day and haematological parameters, Erythrocyte Sedimentation Rate (ESR), vascular permeability were measured.
Results: Phytochemical evaluation revealed the presence of alkaloids, cardiac glycosides, carbohydrates, tannins, flavonoids, saponins and phytosterols. In carrageenan induced rat paw edema model methanolic extract of S. Foetida bark (MESF) 1000 mg/kg showed highly significant anti-edematogenic effect at 3rd hr with % oedema inhibition of 50%. In Acute non-immunological Arthritis model, MESF 500 and 1000 mg/kg showed maximum inhibition of paw edema, width and height on 6th day of study. Results of haematological parameters, ESR and vascular permeability provide further support to anti-arthritic activity of MESF.
Conclusion: Hence our results confirmed Anti-Arthritic potential of S. Foetida bark and supports the traditional use of bark in rheumatism.
Keywords: Rheumatoid arthritis, Sterculia foetida, Formaldehyde, Carrageenan, edema, Vascular permeability.