Syed Yousuf Hussain*, Afzalunnisa Begum, Rahathunnisa Begum.
Department of Pharmacognosy, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana-500001, INDIA.
ORIGINAL RESEARCH ARTICLE
Volume 7, Issue 1, Page 1-8
*Author for correspondence
E-mail: [email protected]
ABSTRACT
Background: Epilepsy is a serious neurological disorder marked by spontaneous seizures as a result of abnormal neuronal activity in the brain. Epilepsy is caused due to brain tumors, infections, brain injury, but most of the time the cause of epilepsy is not known. Seizures can sometimes be related to a temporary condition, such as exposure to certain drugs, very high fever and abnormal levels of glucose/sodium in the blood. This work is aimed to review components in herbal medicines that have shown anti-epileptic properties.
Methods: Preliminary pharmacognostic study of seeds involved in the determination of proximate values was done. The phytochemical screening of petroleum ether and ethanol extracts revealed the presence of major classes of chemical compounds present in the extracts namely alkaloids, glycosides, saponins, flavonoids, lipids, and amino acids. The screening models, the seizure-inducing drug response, the effective dose, the potential mechanism of these compounds have also been done.
Results: The test extracts and standard showed a highly significant dose-dependent decrease as compared to the negative control group in terms of epilepsy index, potential therapeutic value. Trigonella foenum seeds have potent anti-epileptic activity in zebrafish model tested due to their neuromodulatory as well as anti-convulsant effects.
Conclusion: These results justify the therapeutic use of the extract of seeds by traditional medicine practitioners as a safe herbal remedy to protect from excess neurological damage and to treat epilepsy incidences.
Keywords: Trigonella foenum, Epilepsy, Phytochemical screening, Alkaloids, Glycosides,
Flavonoids.
Background: Epilepsy is a serious neurological disorder marked by spontaneous seizures as a result of abnormal neuronal activity in the brain. Epilepsy is caused due to brain tumors, infections, brain injury, but most of the time the cause of epilepsy is not known. Seizures can sometimes be related to a temporary condition, such as exposure to certain drugs, very high fever and abnormal levels of glucose/sodium in the blood. This work is aimed to review components in herbal medicines that have shown anti-epileptic properties.
Methods: Preliminary pharmacognostic study of seeds involved in the determination of proximate values was done. The phytochemical screening of petroleum ether and ethanol extracts revealed the presence of major classes of chemical compounds present in the extracts namely alkaloids, glycosides, saponins, flavonoids, lipids, and amino acids. The screening models, the seizure-inducing drug response, the effective dose, the potential mechanism of these compounds have also been done.
Results: The test extracts and standard showed a highly significant dose-dependent decrease as compared to the negative control group in terms of epilepsy index, potential therapeutic value. Trigonella foenum seeds have potent anti-epileptic activity in zebrafish model tested due to their neuromodulatory as well as anti-convulsant effects.
Conclusion: These results justify the therapeutic use of the extract of seeds by traditional medicine practitioners as a safe herbal remedy to protect from excess neurological damage and to treat epilepsy incidences.
Keywords: Trigonella foenum, Epilepsy, Phytochemical screening, Alkaloids, Glycosides,
Flavonoids.
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