Accessed - 628 times.

Mohammad Mansoor, Chitta Sai Brahmini*, Srinivasa Rao D.

K.C. Reddy Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh-522 348, India.

ORIGINAL RESEARCH ARTICLE
Volume 3, Issue 2, Page 98-101, May-August 2015.

Article history
Received: 20 July 2015
Revised: 13 August 2015
Accepted: 14 August 2015
Early view: 19 August 2015

*Author for correspondence
E-mail: saibrahmini.chitta@gmail.com

ABSTRACT

Background: In traditional medicine, different parts of Ginkgo biloba Linn are highly valued in the treatment of human diseases including antimicrobial, diuretic, anti-inflammatory activity, hepatoprotective etc. In the present study nephroprotective activity of ethanolic leaves extract of Ginkgo biloba were studied, against gentamicin induced nephrotoxicity in rats.
Material and methods: Gentamicin induced kidney damage, showed significant increase in renal parameters like serum creatinine, serum urea, serum uric acid, blood urea nitrogen and weight of kidney.
Results: Administration of ethanolic leaves extracts of Ginkgo biloba 200 mg/kg, p.o. and 400 mg/kg, p.o. sufficiently decreased altered parameters near to normal level indicating the nephroprotective activity of Ginkgo biloba.
Conclusion: Daily treatment with Ginkgo biloba (200 mg/kg and 400 mg/kg) for 8 days conferred nephroprotection on gentamicin induced rats in a dose dependent fashion offered maximum protection.

Keywords: Ginkgo biloba, Nephrotoxicity, Gentamicin, Ethanol, Nephroprotectivity.