ABSTRACT
Background: Cadmium (Cd) is a major environmental pollutant and is known for its wide toxic manifestations. The protective effect of concurrent administration of black grapes (Vitis vinifera) on cadmium-induced renal damage was assessed in rats.
Material and methods: In the present investigation cadmium (5 mg/kg) was administered orally for 4 weeks to induce nephrotoxicity in rats.
Results: Tissue damage induced by cadmium was clearly shown by increased activities of renal markers-serum creatinine and blood urea nitrogen (BUN) along with the increased level of lipid peroxidation indices-TBARS, significantly diminished levels of enzymatic antioxidants such as superoxide dismutases (SOD), catalase, and non-enzymatic antioxidants viz. glutathione (GSH). Administration of black grapes extract significantly reversed activities of serum renal markers to their near-normal levels, significantly decreased lipid peroxidation, restored the antioxidant defense levels of in kidney, and produced improvement in hematological parameters when compared to cadmium-treated rats.
Conclusion: The present study suggested that black grapes may be beneficial in ameliorating the cadmium-induced oxidative damage in the kidneys of rats.