One of the basic differences between modern medicine (Allopathic) and indigenous medicine (like Unani) is that the earlier deals with a particular constituent/component/moiety while systems like Unani medicine relies on holistic approach. Converting entire crude form of a drug into a dosage form poses problems to a pharmaceutical scientists which result into a large dosage size, increased dosing regimen, inadequate mixing of different crude drugs and patient non-compliance (geriatrics, pediatrics and non-conscious). Now we are laden with techniques like nanotechnology (e.g., NE technology). By judicious exploration of technology we can think of dosage forms that can address the challenges being faced and also complying with formula of ancient scriptures (Qrabadeen). This may be successfully explored in liquid dosage forms like Jushanda, Khasanda, Haleeb, Sharbat and other types of sayyal. It can also be explored for external dosage forms (liquid and semi-solid). A genuine effort and ability to think out of the box would definitely pave the way for amalgamation of NE technology with Unani system of medicine.