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Arsalan Rasheed1*, Malaika Noor2, Bakht Beland3, Zahid Mehboob4, Abrar Hussain3, Syed Anees Ali5, Laila Aziz6, Hamid Mehmood7, Noor ul Akbar2, Nargis Sardar8, Muhammad Sajid3,7.
1Department of Zoology, Abdul Wali Khan University Mardan, Pakistan (ORCID: 0000-0001-8576-9289).
2Department of Zoology, Kohat University of Science & Technology, Pakistan.
3Department of Biological Sciences, International Islamic University, Islamabad, Pakistan.
4Institute of Molecular Biology & Biotechnology Department, University of Lahore, Pakistan.
5Research Associate, Allama Iqbal Open University, Islamabad, Pakistan.
6Department of Microbiology, Women University Mardan, Pakistan.
7Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Pakistan.
8Department of Material Science and Electrical Engineering, State Research Institute, Center for Physical Sciences and Technology Vilnius, Lithuania.

ORIGINAL RESEARCH ARTICLE
Volume 10, Issue 1, Page 1-9.

*Author for correspondence
E-mail: arsalanrrasheed@gmail.com

DOI:

ABSTRACT
Aim: This study was designed to study the gastrointestinal helminths in Rattus norvegicus to assess the relevance of rats as the carrier of zoonotic parasites for public health.
Material and Methods: A study of the effects of helminth parasites on rats’ gastrointestinal tract was conducted with the help of Randox kits. Rattus norvegicus used in the study were trapped from different locations in Pakistan and then maintained and raised in live traps under natural temperature. The rats received a daily ration of barley and water. Gastrointestinal tract organs were separated from the body cavity of dissected rats (intestine, stomach, pancreas, liver, lungs, and rectum). Thereafter, total protein & lipase determination was carried out from these organs.
Results: The activity of the total protein in the intestine, stomach, and lungs was increased in infected Rattus norvegicus as compared to the non-infected, while the activity of the total protein in the pancreas, liver, and rectum was found significantly decreased in infected rats as compared to non-infected rats. The activity of lipase in the intestine, stomach, pancreas, and lungs in infected Rattus norvegicus was higher as compared to the non-infected. While the activity of lipase in the liver and rectum was found lower in infected rats as compared to the non-infected rats.
Conclusion: It was observed that helminth infection increased the activity of lipase in the intestine, stomach, pancreas, and lungs; while the decreased activity of lipase was observed in the liver and rectum.
Keywords: Helminth, Parasitic Infection, Norway Rat, Rattus Norvegicus, Gastrointestinal Tract.