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Shamshad Alam*, Naeem A Khan
Department of Ilmul Advia, AK Tibbiya College, AMU, Aligarh-UP, India.

SHORT COMMUNICATION
Volume 3, Issue 1, Page 37-41, January-April 2015.

Article history
Received: 10 February 2015
Revised: 04 March 2015
Accepted: 11 March 2015
Early view: 15 April 2015

*Author for correspondence
E-mail: shamshadalig@gmail.com

ABSTRACT

The present study was designed to establish the possible curative effects of Dawa-ul-Qust (a Unani compound drug) by its crude as well as 50% hydro-alcoholic extract on Carbon tetra chloride (CCl4) induced liver injury in rats. Toxic control, standard (Silymarin) and test drug (crude and extract forms) treated rats were received a single dose of Carbon tetra chloride (CCl4) (2 ml/kg) on 2nd day of study. Antihepatotoxic potential was assessed by the estimation of biochemical markers; viz. serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and Malondialdehyde (MDA) levels. The histopathological examinations of rat livers were also studied to authenticate the biochemical findings. In post-treatment groups, rats were treated with Silymarin at a dose of (10mg/100g) and test drug (Dawaul Qust) at doses of 500 mg/kg and 74.9 mg/kg of body weight respectively in crude as well as in extract forms after Carbon tetra chloride (CCl4) administration. Rats treated with the test drug after the establishment of Carbon tetra chloride (CCl4) induced liver damage showed significant (p=0.001) protection of liver as evidenced from the reduction in the serum transaminases [aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lipid peroxide levels, as both the doses forms exhibited significant reduction in biochemical markers and Malondialdehyde (MDA) levels. Carbon tetra chloride (CCl4) poisoned rats showed significant elevation of biochemical markers and Malondialdehyde level compared to normal control group as well as post treatment groups. The histopathological study supported the hepatocurative activity of the test drug. In conclusion, the findings of the present study suggest that Dawa-ul-Qust possesses potent curative effect against Carbon tetra chloride (CCl4) rendered liver injury in rats.

Keywords: curative effect, hydro-alcoholic extract, biochemical markers, Malondialdehyde