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Lakshmi BVS *, Sudhakar M, Aparna M
Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally Maisammaguda, Secunderabad-500014, AP, India.


Volume 2, Issue 1, Jan-April 2014.

Article history
Received: 04 April 2014
Revised: 20 April 2014
Accepted: 26 April 2014
Early view: 28 April 2014

*Author for correspondence
Mobile/ Tel.: +91 9885324334

Vitis vinifera

ABSTRACTBackground: Cadmium (Cd) is a major environmental pollutant and is known for its wide toxic manifestations. The protective effect of concurrent administration of black grapes (Vitis vinifera) on cadmium-induced renal damage was assessed in rats.
Material and methods: : In the present investigation cadmium (5 mg/kg) was administered orally for 4 weeks to induce nephrotoxicity in rats.
Results: Tissue damage induced by cadmium was clearly shown by increased activities of renal markers-serum creatinine and blood urea nitrogen (BUN) along with the increased level of lipid peroxidation indices-TBARS, significantly diminished levels of enzymatic antioxidants such as superoxide dismutases (SOD), catalase, and non-enzymatic antioxidants viz. glutathione (GSH). Administration of black grapes extract significantly reversed activities of serum renal markers to their near-normal levels, significantly decreased lipid peroxidation, restored the antioxidant defense levels of in kidney, and produced improvement in hematological parameters when compared to cadmium-treated rats.