ABSTRACT
Background: The aim of the study to investigate the anti-urolithiasis activity of curcumin against ethylene glycol-induced urolithiasis in the rat model and its possible fundamental mechanisms.
Material and methods: Here we have measured the concentration of phosphorus and calcium and lowered concentration of magnesium in the urine of the stone induced group and evaluated kidney pathophysiological.
Results: Results indicate that ethylene glycol feeding to rats causes hyperoxaluria, hypercalciuria, as well as increased renal excretion of phosphate. Supplementation with the suspension of curcumin significantly prevented changes in urinary calcium, oxalate, and phosphate excretion dose-dependently. The increased calcium and oxalate level and a number of calcium oxalate crystal in the kidney tissue of calculogenic rats were significantly reverted by supplementation with the suspension of curcumin.
Conclusion: These results are indicating that suspension of curcumin is significantly effective against urolithiasis.
Keywords: Curcumin, Ethylene glycol, Urolithiasis.