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Mohammad Mansoor, Mohan T*, Srinivasa Rao D.

K.C. Reddy Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh-522 348, India.

ORIGINAL RESEARCH ARTICLE
Volume 3, Issue 2, Page 89-92, May-August 2015.

Received: 17 July 2015
Revised: 10 August 2015
Accepted: 12 August 2015
Early view: 14 August 2015

*Author for correspondence
E-mail: : tmohan61@yahoo.com

ABSTRACT
Background: To main aim of the study is to investigate the vitro antioxidant and hypolipidemic activity of Hibiscus cannabinus against high cholesterol diet induced hyperlipidemia in rats for 30 days.
Material and methods: Rats were fed with ethanolic leaves extract of Hibiscus cannabinus (250 mg/kg and 250 mg/kg p.o.) and atorvastatin (30 mg/kg, p.o.) along with hyperlipidemic diet for 30 days.
Results: Ethanolic leaves extract of Hibiscus cannabinus and atorvastatin were found to lower the serum cholesterol, triglyceride, VLDL, LDL levels and increase the HDL leaves as compared to the corresponding high fed cholesterol diet group. The hypolipidemic activity of Hibiscus cannabinus can be ascribed to its inhibitory effect on the liver HMG CoA reductase activity.
Conclusion: The study demonstrates that Hibiscus cannabinus possesses a hypolipidemic effect.
Keywords: Hibiscus cannabinus, HMG Co-A reductase, hypolipidemic effect, lipid profile.