Md Shoaib uddin Khateeb1*, Pawan Kumar1, Syed Safiullah Ghori2.
1School of Pharmacy and Medical Sciences, Singhania University, Rajasthan, India.
2Anwar ul Uloom College of Pharmacy, Hyderabad, Telangana, India.
ORIGINAL RESEARCH ARTICLE
Volume 9, Issue 3, Page 83-88.
*Author for correspondence
E-mail: Shoaib24434@gmail.com
ABSTRACT
Background: Diabetes has become a common global health problem that affects >170 million people worldwide. Traditional medicines obtained from medicinal plants are used by about 40-60% of the world’s population. The present study focused on screening of polyherbal formulation for antidiabetic activity in rats.
Materials and Methods: The present study focused on screening of polyherbal formulation composed of Trigonella foenum-graecum L., Momordica charantia L. & Portulaca oleracea L. (300 mg/kg) in alloxan-induced diabetic rats (150 mg/kg) and with respect to enzymatic assay as such and α- amylase and α-glucosidase inhibition assay.
Results: Polyherbal formulation (PHF) extracts exhibited a significant reduction in α-amylase and α-glucosidase activity with respect to Acarbose, a standard antidiabetic drug. Bodyweight, blood glucose, total cholesterol, and triglycerides level were significantly reduced in PHF treated group as compared to the alloxan-induced diabetic (negative control) group.
Conclusion: The present study successfully demonstrated the antidiabetic activity of PHF in rats.
Keywords: Polyherbal formulation Phytochemicals, Alpha-amylase, Alpha-glucosidase Acarbose, Glibenclamide.
Background: Diabetes has become a common global health problem that affects >170 million people worldwide. Traditional medicines obtained from medicinal plants are used by about 40-60% of the world’s population. The present study focused on screening of polyherbal formulation for antidiabetic activity in rats.
Materials and Methods: The present study focused on screening of polyherbal formulation composed of Trigonella foenum-graecum L., Momordica charantia L. & Portulaca oleracea L. (300 mg/kg) in alloxan-induced diabetic rats (150 mg/kg) and with respect to enzymatic assay as such and α- amylase and α-glucosidase inhibition assay.
Results: Polyherbal formulation (PHF) extracts exhibited a significant reduction in α-amylase and α-glucosidase activity with respect to Acarbose, a standard antidiabetic drug. Bodyweight, blood glucose, total cholesterol, and triglycerides level were significantly reduced in PHF treated group as compared to the alloxan-induced diabetic (negative control) group.
Conclusion: The present study successfully demonstrated the antidiabetic activity of PHF in rats.
Keywords: Polyherbal formulation Phytochemicals, Alpha-amylase, Alpha-glucosidase Acarbose, Glibenclamide.
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