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Md. Najibur Rahman1, Md. Razi Ahmad2, J.U. Takmili3, Akhtar Hussain Farooqui3, Md. Neshat Ahmad3
1Department of Moalejat, Govt. Tibbi College & Hospital, Patna, Bihar, INDIA.
2Department of Moalejat, Salfia Unani Medical College & Hospital Laheriasarai, Darbhanga, Bihar, INDIA.
3Department of Moalejat, ZVM Unani Medical College & Hospital, Pune, Maharashtra, INDIA.

ORIGINAL RESEARCH ARTICLE
Volume 5, Issue 3, Page 206-211.

*Author for correspondence
E-mail: drmdnajibur.rahman@gmail.com

ABSTRACT
Background: Nephrolithiasis is a complex multi-factorial disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. The present study entitled “A Randomized Open-Label Clinical Trial of Khar-e-Khasak (Tribulus Terrestris Linn.) In The Management of Hisat-ul-Kuliyah (Nephrolithiasis)” demonstrates that Safoof-e-Khar-e-Khasak (3 g B.I.D.) has the significant effect on Hisat-ul-Kuliyah.
Subject and methods: The data collected through case Report Proforma after completion of the study, were analyzed statistically and subjected to student “t” test.
Results: The study indicates that this Unani medicine has excellent analgesic, diuretic, relieved burning micturition effect with statistical significance. Further, it is observed during the study period (i.e. 90th day of duration), the extremely significant mean reduction size of the stone in U.S.G. The mean reduction of stone size 5.3833 ± 1.7475, the p-value is <0.001. It suggests that effect of the drug is highly significant, the significant mean reduction was also observed on no. of stone X-ray K.U.B. 0.900 ± 0.611, P = <0.001. It suggests that effect of the drug is highly significant. The mean reduction of B. Urea 3.600 ± 3.68, P = >0.10. It suggests that effect of the drug is not significant. The mean reduction of S. Creatinine 0.071 ± 0.074, P = >0.10. It suggests that effect of the drug is not significant. The extremely significant mean reduction of urinary pH value 0.2400 ± 0.803, P = <0.05. Conclusion: It suggests that effect of the drug is significant.
Keywords: Khar-e-Khasak, Hisat-ul-Kuliyah.