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Anant Prakash Pandey*, Santosh Kumar Shukla.
Institute of Pharmaceutical Sciences & Research, Unnao, UP, India.

Volume 10, Issue 2, Page 76-81.

*Author for correspondence


The main risk factor for the emergence and spread of neurodegenerative disorders (ND) is age. The growth in ND prevalence, particularly in emerging nations, is thought to be mostly caused by the expansion of longevity. The challenge for doctors and researchers is to find treatment approaches able to slow down neurodegeneration and/or improve the patient’s quality of life because there is currently no cure for any of them. Increased cellular oxidative stress has been identified as one of the potential risk factors in ND, along with genetics and environmental stresses. The antioxidant effects of a heterogeneous class of natural substances known as nutraceuticals, including vitamins, carotenoids, and polyphenols, have drawn the attention of the scientific community in recent years. Among polyphenols, resveratrol and curcumin. Although polyphenols have substantial antioxidant properties, their poor bioavailability and quick metabolism are the main factors that limit their ability to provide neuroprotection. Polymeric nanoparticle-based polyphenol delivery systems, which stop bioactive compounds from degrading and increase their absorption and bioavailability, offer a viable option. The bioavailability of polyphenols is now enhanced by food-grade lipid-based nanoparticles, polysaccharide nanoparticles, nanoemulsions, biopolymeric nanoparticles, nanocomplexes (proteins, carbohydrates), and copolymers (protein-carbohydrate conjugates). The enormous potential of nanoparticle-based systems for the administration of nutraceuticals may make them an effective therapeutic approach for the management of ND.
Keywords: Aging, Neurodegenerative disease, Polyphenols, Bioavailability, Solubility, Nanoparticle-based delivery systems.