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Mohammad Mansoor, Kota Ashok*, Srinivasa Rao D.

K.C. Reddy Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh-522 348, India.

Volume 3, Issue 2, Page 93-97, May-August 2015.

Received: 18 July 2015
Revised: 12 August 2015
Accepted: 14 August 2015
Early view: 18 August 2015

*Author for correspondence


Background: Diabetes is a metabolic disorder associated with hyperglycemia and caused by defect in insulin secretion. The aim of the present study was to evaluate the antidiabetic activity of Artemisia dracunculus L in alloxan induced diabetic rats.
Material and methods: The antidiabetic effect of Artemisia dracunculus L was studied against alloxan (140 mg/k g b.w., i.p.) induced diabetes in Wistar rats for doses 250 mg/kg b.w. and 500 mg/kg b.w. (p.o.) for four weeks and the effect was compared with standard glibenclamide (10 mg/kg, b.w).
Results: Diabetes induced by alloxan treatment increases the level of glucose and biochemical parameter in blood sample but treatment with Artemisia dracunculus L significant decrease the elevated glucose and blood biochemical parameter.
Conclusion: Hence, the results obtained in the present study indicate that Artemisia dracunculus L posses significant anti-diabetes activity.
Keywords: Artemisia dracunculus L, Alloxan, Biochemical parameter, Glibenclamide.