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V. Rajesh Babu1*, V. Mallikarjun2, Syeda Rana Nikhat1.
1Department of Pharmaceutics, MESCO College of Pharmacy, Hyderabad, T.S., INDIA.
2Department of Pharmaceutics, Chaitanya College of Pharmacy Education & research, Hanamkonda, T.S., INDIA.

Volume 5, Issue 4, Page 236-240.

*Author for correspondence

Aim: The present investigation was aimed to prepare loratidine solid dispersions by solvent evaporation method using gelucire 44/14 and 50/13 as hydrophilic carriers.
Material and methods: Solid dispersion of loratidine with Gelucire 44/14 and Gelucire 50/13 were prepared using different weight ratios of three different hydrophilic carriers were prepared by the solvent evaporation method. Accurately weighed amount of drug and polymers in various ratios dissolved in ethanol in a round bottom flask and the solvent was evaporated at 45°C temperature.
Results: From the in vitro drug release studies the optimized formulation F3 containing gelucire 44/14 showed almost complete drug release within the 15 min. The percent drug release in 15 min (Q15) and initial dissolution rate (IDR) for optimized formulation (F3) was 94.22±1.08%, 9.26%/min. These were very much higher compared to the pure drug (23.87±1.13%, 2.38%/min). The improvement in the dissolution characteristics of a drug described in terms of dissolution efficiency (DE) and relative dissolution rate (RDR). The RDR was found to be 2.14. The DE was found to be 67.52 and it is increased by 4.0 fold with optimized FDT formulation compared to conventional tablets.
Conclusion: In conclusion, development of the solid dispersions can be a promising alternative method to attain the fast dissolution rate and absorption for water-insoluble drugs like loratadine and it was achieved with Gelucire 44/14 as a carrier.
Keywords: Loratidine, Gelucire, Solid Dispersion, Initial Dissolution Rate.