Carbamazepine loaded mucoadhesive solid lipid nanoparticle: Formulation and in-vitro characterization

Mohammad Wasif Khan1*, M. J. Ahsan2, Sushil Kumar Gupta3
1Dept of Pharmaceutical Sciences, Sunrise University, Alwar, Rajasthan- 301026, INDIA.
2Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan-302039, INDIA.
3Sunrise University, Alwar, Rajasthan-301026, INDIA.

ORIGINAL RESEARCH ARTICLE
Volume 2017, Issue 2017, Article ID 130, Page 01-09.

*Author for correspondence
E-mail: kunwarwasif@gmail.com

ABSTRACT
Background: By the oral route of administration, bioavailability of Carbamazepine is low and variable. In the present study, Carbamazepine-loaded solid lipid nanoparticles (SLNs) were prepared with the aim to enhance the uptake of CBZ to brain via intranasal delivery.
Material and methods: SLNs were prepared by modified emulsification–diffusion technique and evaluated for particle size, zeta potential, drug entrapment efficiency, in vitro drug release. The SLNs developed were used to develop thermosensitive and mucoadhesive gel by using carbopol and Pluronic F127. The gels were evaluated in vitro.
Results: The optimized SLN was characterized for % EE (90.63 ± 0.48), drug content (20.59 ± 0.11), mean particle size (331.4 nm), zeta potential (-32.6±2.6) and PDI (0.473). In-vitro release showed 62.2% CBZ release in 20 hrs. Furthermore, shelf life predicted for the optimized formulation was 0.78 years.
Conclusions: The studies demonstrate that the formulation can be tested and used for nasal route for improved delivery of CBZ.
Keywords: Solid lipid nanoparticle (SLN), carbamazepine, surfactant, mucoadhesive, nasal delivery.