Background: The dual antimicrobial and antioxidant effects of Capparis spinosa seed oil prompted us to formulate the solid lipid nanoparticles of aforesaid oil and evaluate their antiacne effect against P. acne using erythromycin as standard.
Material and methods: Capparis spinosa seed oil loaded solid lipid nanoparticles were prepared using w/o/w type double emulsification method & its drug polymer compatibility was analyzed by FT-IR & HPLC. Surface morphology (by TET) showed that the particles has evident round and homogeneous shading, the particle size of Capparis spinosa seed oil loaded SLNs ranging approximately from 290-697nm. Zeta potential of -32mV also confirmed the stability of colloidal dispersion. The G4 formulation of SLN showed maximum entrapment (83%) due to high affinity of drug with lipid matrix. During the period of storage, the formulation showed no change in colour, creaming and phase separation. The G4 formulations showed significantly less drug release over other formulations & showed significant activity at concentration of 50 ?g/mL &100 ?g/mL but on further increase no significant change in zone of inhibition was observed.
Results: Formulation of Capparis spinosa seed oil loaded solid lipid nanoparticles has good stability, no drug polymer interaction; nanoparticles size approximately 290-697nm (spherical). Test sample G4 showed sustained drug release and significant anti-acne activity against P. acne using cup-plate method.
Conclusion: The results of oil loaded SLNs showed average diameters in the narrow colloidal size range, a good loading capacity, drug release and better anti-acne activity. The oil loaded SLNs methodology and nanoemulsions developed may open a new door towards the treatment acne.

Keywords: P. acne, Oil loaded solid lipid nanoparticles, Capparis spinosa seed, Erythromycin.